Antimony salt-promoted cyclization facilitating on-DNA syntheses of dihydroquinazolinone derivatives and its applications
DNA-encoded chemical libraries technology has become a novel approach to finding hit
compounds in early drug discovery. The chemical space in a DEL would be expanded to …
compounds in early drug discovery. The chemical space in a DEL would be expanded to …
Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries
H Wang, T Chen, X Fan, Y Li, W Fang… - Chemical …, 2024 - pubs.rsc.org
The versatile reactivity of isothiocyanate intermediates enabled the diversity-oriented
synthesis (DOS) of N-heterocycles in a DNA-compatible manner. We first reported a mild in …
synthesis (DOS) of N-heterocycles in a DNA-compatible manner. We first reported a mild in …
On-DNA Synthesis of Functionalized 4H-Pyran Scaffolds for Focused DNA-Encoded Chemical Libraries
Y Gao, Y Sun, G Zhao, G Zhang, Y Li, Y Li - Organic Letters, 2022 - ACS Publications
The functionalized 4 H-pyran scaffold has aroused synthetic attention because it is widely
found in many interesting pharmacologically relevant compounds. We here disclose its …
found in many interesting pharmacologically relevant compounds. We here disclose its …
Incorporation of viridicatin alkaloid-like scaffolds into DNA-encoded chemical libraries
X Fang, H Liao, X Fan, Y Wang, H Wang… - Organic & …, 2023 - pubs.rsc.org
Viridicatin alkaloids as natural products have attracted great interest due to their unique core
scaffold. To fully exploit their potential application in DNA-encoded chemical libraries that …
scaffold. To fully exploit their potential application in DNA-encoded chemical libraries that …
Aryl diazonium intermediates enable mild DNA-compatible C–C bond formation for medicinally relevant combinatorial library synthesis
X Li, J Zhang, C Liu, J Sun, Y Li, G Zhang, Y Li - Chemical Science, 2022 - pubs.rsc.org
Forging carbon–carbon (C–C) linkage in DNA-encoded combinatorial library synthesis
represents a fundamental task for drug discovery, especially with broad substrate scope and …
represents a fundamental task for drug discovery, especially with broad substrate scope and …
Electrochemically induced synthesis of imidazoles from vinyl azides and benzyl amines
VA Vil', SS Grishin, AO Terent'ev - Molecules, 2022 - mdpi.com
An electrochemically induced synthesis of imidazoles from vinyl azides and benzyl amines
was developed. A wide range of imidazoles were obtained, with yields of 30 to 64%. The …
was developed. A wide range of imidazoles were obtained, with yields of 30 to 64%. The …
I 2/TBHP-mediated oxidative cascade cyclization of vinyl azide and benzylamine to construct 2, 5-disubstituted oxazoles
A one-pot facile synthesis of disubstituted oxazoles has been achieved from vinyl azide and
benzylamine. A coherent mixture of iodine and tert-butyl hydroperoxide (TBHP) efficiently …
benzylamine. A coherent mixture of iodine and tert-butyl hydroperoxide (TBHP) efficiently …
Five-membered ring systems: with more than one N atom
L Yet - Progress in Heterocyclic Chemistry, 2023 - Elsevier
The synthesis and chemistry of pyrazoles, imidazoles, 1, 2, 3-triazoles, 1, 2, 4-triazoles, and
tetrazoles were actively pursued in 2022. No attempt was made to incorporate all the …
tetrazoles were actively pursued in 2022. No attempt was made to incorporate all the …