Abstract Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian
system, which is deleterious to health. In industrialized countries, 75% of the total workforce …

Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Mammalian adipose tissue is traditionally categorized into white and brown relating to their
function and morphology: while white serves as an energy storage, brown adipose tissue …

Melatonin is an old and ubiquitous molecule in nature showing multiple mechanisms of
action and functions in practically every living organism. In mammals, pineal melatonin …

Igniting thermogenesis within white adipose tissue (ie, promoting expression and activity of
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …

It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

Almost all living organisms have evolved autoregulatory transcriptional‐translational
feedback loops that produce oscillations with a period of approximately 24‐h. These …

Excess weight and obesity are severe public health threats worldwide. Recent evidence
demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The …