In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Vascular anomalies include various diseases, which are classified into two types according
to the International Society for the Study of Vascular Anomalies (ISSVA) classification …

Vascular and lymphatic malformations represent a challenge for clinicians. The identification
of inherited and somatic mutations in important signaling pathways, including the PI3K …

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF …

Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors,
they have the unique ability to involute after proliferation, often leading primary care …

Background The aetiology and exact incidence of infantile haemangiomas (IHs) are
unknown. Prior studies have noted immunohistochemical and biological characteristics …

Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more
typically referred to as birthmarks. Subcategorized into vascular tumors and malformations …

OBJECTIVE: Infantile hemangiomas (IHs) are the most-common soft-tissue tumors of
infancy. We report the use of propranolol to control the growth phase of IHs. METHODS …

Venous malformations (VMs) are composed of ectatic veins with scarce smooth muscle cell
coverage. Activating mutations in the endothelial cell tyrosine kinase receptor TIE2 are a …

The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients
into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In …