Biomineralization is the process by which hydroxyapatite is deposited in the extracellular
matrix. Physiological mineralization occurs in hard tissues, whereas pathological …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Osteoporosis is a major concern all over the world. With aging, a gradual loss of bone mass
results in osteopenia and osteoporosis. Heritable factors account for 60–80% of optimal …

Background Osteoporosis mainly occurs in postmenopausal women, which is characterized
by low bone mineral density (BMD) due to unbalanced bone resorption by osteoclasts and …

A variety of in vivo models have increased understanding of the role of Wnt signaling in
bone since mutations in the LRP5 gene were found in human bone disorders. Canonical …

To identify and validate genes associated with bone mineral density (BMD), which is a
prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white US …

Osteoporosis, a highly heritable disease, is characterized mainly by low bone-mineral
density (BMD), poor bone geometry, and/or osteoporotic fractures (OF). Copy-number …

Context: The primary goals of genome-wide association studies (GWAS) are to discover new
molecular and biological pathways involved in the regulation of bone metabolism that can …

A family history of hip fracture carries a twofold increased risk of fracture among
descendants. Genetic factors indeed play a major role in the determination of bone mineral …

Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …