Only natural selection can account for the extreme genetic diversity of genes of the major
histocompatibility complex (MHC). Although the structure and function of classic MHC genes …

Objective: This review focuses on the current knowledge on the implication and significance
of beta 2 microglobulin (β2M), a conservative immune molecule in vertebrate. Data Sources …

Perforin-deficient mice have been generated by homologous recombination to determine
whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore …

In this study, we have examined the relative contributions of CD4+ and CD8+ T cells in
controlling an acute or chronic lymphocytic choriomeningitis virus (LCMV) infection. To study …

Mice with a targeted disruption in the beta 2-microglobulin (beta 2m) gene, which lack major
histocompatibility complex class I molecules and consequently fail to develop functional …

A transgenic mouse expressing MHC class II‐restricted TCR with specificity for a
lymphocytic choriomeningitis virus (LCMV) glycoprotein‐derived T helper cell epitope was …

The rules for T‐cell‐mediated control of viruses that infect via the respiratory mucosae show
both common themes and differences depending on the nature of the pathogen. Virus …

Mice with disrupted beta 2-microglobulin (beta 2m-/-), IA (class II-/-), or CD4 (CD4-/-) genes
were examined for their capacity to resolve Chlamydia trachomatis genital tract infection …

A unique experimental model has been developed for dissecting the integrity of CD8+ T cell-
mediated immunity to a persistent gammaherpesvirus under conditions of CD4+ T cell …

CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in
humans, mice, and other species in response to many diverse pathogens. Since CD4 …