Cisplatin is widely used chemotherapeutic drug and have some serious side effects as
tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug …

Urotensin II (UII) is a polypeptide molecule with neurohormone-like activity. It has been
confirmed that UII is widely distributed in numerous organs of different animal species from …

Aims Sepsis is a complex pathophysiological event involving systemic inflammatory
response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute …

Objective Butein is a potential agent first isolated from Rhus verniciflua that has medicinal
value in East Asia and has been used in the treatment of gastritis, gastric cancer, and …

The aim of the study was to examine the protective effects and possible mechanism of
gossypin against isoproterenol (ISO)-mediated myocardial damage in vivo and H9c2 cell …

Abstract Background/Aims Sepsis is an uncontrolled systemic infection, withcomplex
pathophysiology that may result in acute lung organ damage and cause multiple organ …

The urotensinergic system, comprised of a G protein-coupled receptor (UT) and two
endogenous ligands named urotensin II (UII) and urotensin II-related peptide (URP), has …

The presence of 5-HT7r's in both human and rat cardiovascular and immune tissues and
their contribution to inflammatory conditions prompted us to hypothesize that these receptors …

Paracetamol is one of the drugs that cause hepatic damage. Fisetin has wide
pharmacological effects such as anticancer, antiinflammatory and antioxidant. We aimed to …

Peptides have recently regained interest as therapeutic candidates, but their development
remains confronted with several limitations including low bioavailability. Backbone head-to …