ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …

Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Background Hypoxia is a major cause of beta cell death and dysfunction after
transplantation. The aim of this study was to investigate the effect of exosomes derived from …

To achieve preferential effects against cancer cells but less damage to normal cells is one of
the main challenges of cancer research. In this review, we explore the roles and …

Cancer represents a serious global health problem, and its incidence and mortality are
rapidly growing worldwide. One of the main causes of the failure of an anticancer treatment …

Cervical cancer is the fourth most common cancer among women worldwide. Though
several natural products have been reported regarding their efficacies against cervical …

As the leading cause of cancer death, cervical cancer ranks fourth for both incidence and
mortality. Cervical cancer incidence and mortality rates have reportedly decreased over the …

Steroidal saponins are a group of glycosides widely distributed among monocotyledonous
families. They exert a wide spectrum of biological effects including cytotoxic and antitumor …

The present study emphasized on the anti-cancerous effects of dioscin and its underlying
molecular mechanism in human endometrial cancer Ishikawa cells. Dioscin significantly …

Bladder cancer is one of the most common malignancies of the male genitourinary urinary
system. Protodioscin is a steroidal saponin with anti-cancer effects on several types of …