The demand for high-throughput data collection in electron microscopy is increasing for
applications in structural and cellular biology. Here we present a combination of software …

Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division. To
support this malignant phenotype, cells acquire molecular alterations that abrogate or …

Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of
human tumors. Enforced centrosome amplification in vivo plays a role in tumor initiation and …

Replication stress, a hallmark of cancerous and pre-cancerous lesions, is linked to structural
chromosomal aberrations. Recent studies demonstrated that it could also lead to numerical …

Somatic rearrangements resulting in genomic structural variation drive malignant
phenotypes by altering the expression or function of cancer genes. Pan-cancer studies have …

Centrosome aberrations are hallmarks of human cancers and contribute to the senescence
process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular …

Chromosomal instability (CIN) comprises continual gain and loss of chromosomes or parts
of chromosomes and occurs in the majority of cancers, often conferring poor prognosis …

α/β-Tubulin posttranslational modifications (PTMs) generate microtubule diversity, but
whether they account for cancer cell resistance to microtubule-targeting drugs remains …

Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium.
Using proteomics and superresolved imaging, we identify a module that we term DISCO …

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment
of centrosomes, a state referred to as centrosome amplification (CA). CA can drive …