Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilize
during adulthood, ensuring lifelong hippocampal neurogenesis. We show that this …

The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural
stem cells exhibit features of astrocytes, have a regional identity, and depending on their …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Notch signaling is an evolutionarily conserved pathway that regulates important biological
processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation …

Ectopic expression of defined transcription factors can force direct cell-fate conversion from
one lineage to another in the absence of cell division. Several transcription factor cocktails …

Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly
quiescent, and only a few are in cell cycle at any point in time. DG NSCs become …

Although the role of NOTCH signaling has been extensively studied in health and disease,
many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH …