Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle,
cilia, and bundles inside neurons. How microtubules are regulated to enable specific …

All microtubules are built from a basic α/β-tubulin building block, yet subpopulations of
microtubules can be differentially marked by a number of post-translational modifications …

Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex
microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation …

Posttranslational glutamylation of tubulin is present on selected subsets of microtubules in
cells. Although the modification is expected to contribute to the spatial and temporal …

Microtubules–polymers of tubulin–perform essential functions, including regulation of cell
shape, intracellular transport and cell motility. How microtubules are adapted to perform …

Tubulin undergoes several highly conserved posttranslational modifications (PTMs)
including acetylation, detyrosination, glutamylation, and glycylation. These PTMs …

In 1993, an enzyme with an ATP-dependent microtubule-severing activity was purified from
sea urchin eggs and named katanin, after the Japanese word for sword. Now we know that …

Spastin, the most common locus for mutations in hereditary spastic paraplegias, and katanin
are related microtubule-severing AAA ATPases,,,, involved in constructing neuronal,,, and …

Microtubules are very dynamic polymers whose assembly and disassembly is determined
by whether their heterodimeric tubulin subunits are in a straight or curved conformation …

Benzimidazoles (BZ) are essential components of the limited chemotherapeutic arsenal
available to control the global burden of parasitic nematodes. The emerging threat of BZ …