Real-world studies have become increasingly important in providing evidence of treatment
effectiveness in clinical practice. While randomized clinical trials (RCTs) are the “gold …

Background Despite increasing recognition of the value of real-world data (RWD),
consensus on the definition of RWD is lacking. Objectives To review definitions publicly …

Aim Chemotherapy side effects are often reported in clinical trials; however, there is little
evidence about their incidence in routine clinical care. The objective of this study was to …

Purpose Real‐world evidence (RWE) includes data from retrospective or prospective
observational studies and observational registries and provides insights beyond those …

Real-world evidence (RWE) and randomized control trial (RCT) data are considered
mutually complementary. However, compared with RCT, the outcomes of RWE continue to …

Evidence from medication use in the real world setting can help to extrapolate and/or
augment data obtained in randomized controlled trials and establishes a broad picture of a …

Non-communicable diseases, including cancer, are overtaking infectious disease as the
leading health-care threat in middle-income and low-income countries. Latin American and …

The burden of cancer is growing, and the disease is becoming a major economic
expenditure for all developed countries. In 2008, the worldwide cost of cancer due to …

Bisphosphonates (BPs) are well established as the leading drugs for the treatment of
osteoporosis. There is new knowledge about how they work. The differences that exist …

Health technology assessment (HTA) is a dynamic, rapidly evolving process, embracing
different types of assessments that inform real-world decisions about the value (ie, benefits …