Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

Key determinants for the development of an allergic response to an otherwise 'harmless'
food protein involve different factors like the predisposition of the individual, the timing, the …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

The availability of allergen molecules ('components') from several protein families has
advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled …

The non-specific lipid transfer proteins (LTPs) constitute a large protein family found in all
land plants. They are small proteins characterized by a tunnel-like hydrophobic cavity, which …

The panallergen concept encompasses families of related proteins, which are involved in
general vital processes and thus, widely distributed throughout nature. Plant panallergens …

Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens.
These proteins are induced by the plants as a defense response system in stress conditions …

Plant lipid‐transfer proteins (LTPs) are abundant, small, lipid binding proteins that are
capable of exchanging lipids between membranes in vitro. Despite their name, a role in …

Background Multiple plant‐food sensitizations with a complex pattern of clinical
manifestations are a common feature of lipid transfer protein (LTP)‐allergic patients …

Progressive knowledge of allergenic structures resulted in a broad availability of allergenic
molecules for diagnosis. Component‐resolved diagnosis allowed a better understanding of …