[HTML][HTML] Repurposed itraconazole for use in the treatment of malignancies as a promising therapeutic strategy

CL Li, ZX Fang, Z Wu, YY Hou, HT Wu, J Liu - Biomedicine & …, 2022 - Elsevier
Understanding cancer biology and the development of novel agents for cancer treatment
has always been the goal of cancer researchers. However, the research and development of …

[HTML][HTML] Repurposing antifungal drugs for cancer therapy

N Weng, Z Zhang, Y Tan, X Zhang, X Wei… - Journal of Advanced …, 2023 - Elsevier
Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

Cancer metabolism as a therapeutic target and review of interventions

MTJ Halma, JA Tuszynski, PE Marik - Nutrients, 2023 - mdpi.com
Cancer is amenable to low-cost treatments, given that it has a significant metabolic
component, which can be affected through diet and lifestyle change at minimal cost. The …

[HTML][HTML] The roles and mechanisms of the lncRNA-miRNA axis in the progression of esophageal cancer: a narrative review

T Huang, Z Wu, S Zhu - Journal of thoracic disease, 2022 - ncbi.nlm.nih.gov
Methods Related articles published in the PubMed database between 05/30/2008 to
09/10/2022 were identified using the following terms:“lncRNA AND miRNA AND esophageal …

First-line gemcitabine, nab-paclitaxel, and oxaliplatin chemotherapy with itraconazole in patients with metastatic pancreatic cancer: a single institution experience

M Sawasaki, H Tsubamoto, A Sugihara… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Combination chemotherapy with gemcitabine, nab-paclitaxel, oxaliplatin,
and itraconazole (GnPO-ITC) was administered as first-line chemotherapy in patients with …

Itraconazole inhibits the growth of cutaneous squamous cell carcinoma by targeting HMGCS1/ACSL4 axis

C Xu, Y Zhuo, Y Liu, H Chen - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous cancer
with increasing incidence. Itraconazole has been identified as a potential anticancer drug …

Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen

RE Kast, A Alfieri, HI Assi, TC Burns, AM Elyamany… - Cancers, 2022 - mdpi.com
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD)

Z Lahmar, E Ahmed, A Fort, I Vachier, A Bourdin… - Pharmacology & …, 2022 - Elsevier
COPD affects millions of people and is now ranked as the third leading cause of death
worldwide. This largely untreatable chronic airway disease results in irreversible destruction …

Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer?

R ArefNezhad, F Rezaei‐Tazangi… - Cell Biology …, 2023 - Wiley Online Library
Esophageal cancer (EC), as one of the leading causes of cancer‐associated mortality,
influences a remarkable population of subjects globally and is histologically divided into two …

Itraconazole Reversing Acquired Resistance to Osimertinib in NSCLC by Inhibiting the SHH/DUSP13B/p‐STAT3 Axis

H Zheng, Y Tang, H Zang, J Luo, H Zhou… - Advanced …, 2024 - Wiley Online Library
There is an urgent necessity to devise efficient tactics to tackle the inevitable development of
resistance to osimertinib, which is a third‐generation epidermal growth factor receptor …