Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
Strategies for non-viral vectors targeting organs beyond the liver
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
Frontiers in the treatment of glioblastoma: Past, present and emerging
Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …
research over the last several decades, the survival rates for GBM have not improved and …
Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Progress in brain targeting drug delivery system by nasal route
AR Khan, M Liu, MW Khan, G Zhai - Journal of Controlled Release, 2017 - Elsevier
The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …
pH-responsive polymer nanomaterials for tumor therapy
S Chu, X Shi, Y Tian, F Gao - Frontiers in oncology, 2022 - frontiersin.org
The complexity of the tumor microenvironment presents significant challenges to cancer
therapy, while providing opportunities for targeted drug delivery. Using characteristic signals …
therapy, while providing opportunities for targeted drug delivery. Using characteristic signals …
Drug-loaded lipid magnetic nanoparticles for combined local hyperthermia and chemotherapy against glioblastoma multiforme
Glioblastoma multiforme (GBM) is a devastating tumor of the central nervous system,
currently missing an effective treatment. The therapeutic gold standard consists of surgical …
currently missing an effective treatment. The therapeutic gold standard consists of surgical …
Polymeric nanoparticles in brain cancer therapy: A review of current approaches
Translation of novel therapies for brain cancer into clinical practice is of the utmost
importance as primary brain tumors are responsible for more than 200,000 deaths …
importance as primary brain tumors are responsible for more than 200,000 deaths …
Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease
Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …
Novel nano-drug delivery system for brain tumor treatment
Z Qiu, Z Yu, T Xu, L Wang, N Meng, H Jin, B Xu - Cells, 2022 - mdpi.com
As the most dangerous tumors, brain tumors are usually treated with surgical removal,
radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas …
radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas …