Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …

Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

Inhibitory interneurons are crucial to brain function and their dysfunction is implicated in
neuropsychiatric conditions. Emerging evidence indicates that cholecystokinin (CCK) …

Adolescent individuals exhibit great variability in cortical dynamics and behavioral
outcomes. The developing adolescent brain is highly sensitive to social experiences and …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

Glaucoma is a collection of diseases that lead to an irreversible vision loss due to damage of
retinal ganglion cells (RGCs). Although the underlying events leading to RGC death are not …

The cortex in the mammalian brain is the most complex brain region that integrates sensory
information and coordinates motor and cognitive processes. To perform such functions, the …

Central nervous system parvalbumin-positive interneurons (PV-INs) are crucial and highly
vulnerable to various stressors. They also play a significant role in the pathological …

Background A number of rare copy number variants (CNVs) have been linked to
neurodevelopmental disorders. However, because CNVs encompass many genes, it is often …