Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

NA Du Fossé, MLP Van der Hoorn… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Although spontaneous miscarriage is the most common complication of
human pregnancy, potential contributing factors are not fully understood. Advanced …

Impact of advanced paternal age on fertility and risks of genetic disorders in offspring

A Kaltsas, E Moustakli, A Zikopoulos, I Georgiou… - Genes, 2023 - mdpi.com
The average age of fathers at first pregnancy has risen significantly over the last decade
owing to various variables, including a longer life expectancy, more access to contraception …

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

R Sharma, A Agarwal, VK Rohra, M Assidi… - Reproductive Biology …, 2015 - Springer
Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis

SL Johnson, J Dunleavy, NJ Gemmell… - Ageing research …, 2015 - Elsevier
Reduced fertility typically occurs among women in their late 30s, but increasing evidence
indicates that advanced paternal age is associated with changes in reproduction as well …

Demographic and medical consequences of the postponement of parenthood

L Schmidt, T Sobotka, JG Bentzen… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Across the developed world couples are postponing parenthood. This
review assesses the consequences of delayed family formation from a demographic and …

[HTML][HTML] Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis

D Sakkas, JG Alvarez - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To review the mechanisms responsible for DNA fragmentation in human
sperm, including those occurring during spermatogenesis and transport through the …

Effects of aging on the male reproductive system

S Gunes, GNT Hekim, MA Arslan, R Asci - Journal of assisted reproduction …, 2016 - Springer
The study aims to discuss the effects of aging on the male reproductive system. A systematic
review was performed using PubMed from 1980 to 2014. Aging is a natural process …

Advanced paternal age, infertility, and reproductive risks: a review of the literature

JS Brandt, MA Cruz Ithier, T Rosen… - Prenatal …, 2019 - Wiley Online Library
Advanced paternal age (APA) is associated with infertility and other reproductive risks.
Studies looking at APA and outcomes have used different paternal age cut‐offs, which has …

Sperm DNA fragmentation index influences assisted reproductive technology outcome: A systematic review and meta‐analysis combined with a retrospective cohort …

C Deng, T Li, Y Xie, Y Guo, Q Yang, X Liang… - Andrologia, 2019 - Wiley Online Library
Studies have explored the influence of DNA damage in assisted reproductive technology
(ART), but the outcome remains controversial. To determine whether sperm DNA …

Male reproductive ageing: a radical road to ruin

RJ Aitken - Human Reproduction, 2023 - academic.oup.com
In modern post-transition societies, we are reproducing later and living longer. While the
impact of age on female reproductive function has been well studied, much less is known …