As the aromatic tryptophan (Trp) side chain plays a pivotal role in influencing the structure
and function of peptides and proteins, it has become an attractive target for the late‐stage …

Modified cyclic dipeptides represent a widespread class of secondary metabolites with
diverse pharmacological activities, including antibacterial, antifungal, and antitumor. Here …

Tailoring enzymes are important modification biocatalysts in natural product biosynthesis.
We report herein six orthologous two‐gene clusters for mycocyclosin and guatyromycine …

Cyclodipeptides from fungi and bacteria are often modified by different tailoring enzymes.
They display various biological and pharmacological activities, and some derivatives are …

Heterologous expression of a cdps-p450 locus from Streptomyces sp. NRRL S-1521 led to
the identification of guanitrypmycin D1, a new guaninylated diketopiperazine. The …

Prenylation can impart pharmacological advantages to bioactive compounds. Global
genome mining for prenylated cyclodipeptides identified a gczABC BGC from Streptomyces …

The prenylation of flavonoids is a main type of structural modification and can endow
flavonoids with greater bioactivity and bioavailability. A soluble prenyltransferase (NgFPT) …

Indoles and pyrroloindoles are structural motifs present in many biologically active natural
products. Multiple classes of enzymes catalyze the transformation of indoles into …

Cyclodipeptides (CDPs) build an important class of secondary metabolites with a plethora of
pharmacological impact such as antibiotic, cytotoxic, antifungal properties or even as anti …

Drimentines (DMTs) are a family of bacterial alkaloids featuring a 2, 5-diketopiperazine (2, 5-
DKP) ring with diverse bioactivities. In this study, we characterized the biosynthetic pathway …