Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Transthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate
evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR …

Cerebrospinal fluid (CSF) biomarkers based on the core pathological proteins associated
with Alzheimer's disease (AD), ie, amyloid-β (Aβ) and tau protein, are widely regarded as …

Many protein folding diseases are intimately associated with accumulation of amyloid
aggregates. The amyloid materials formed by different proteins/peptides share many …

Stereochemistry is a very important issue for the pharmaceutical industry and can determine
drug efficacy. The design and synthesis of small molecules, especially chiral molecules …

Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR)
ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR–β-amyloid (Aβ) …

Alzheimer's disease is associated with the deposition of the amyloid-β peptide (Aβ) into
extracellular senile plaques in the brain. In vitro and in vivo observations have indicated that …

Liraglutide is a GLP-1 analog (glucagon like peptide-1) used primarily in the treatment of
diabetes mellitus type 2 (DM2) and obesity. The literature starts to suggest that liraglutide …

Alzheimer's disease (AD) is the most common form of dementia worldwide, being
characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the …