STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges
GL Wong, SG Manore, DL Doheny, HW Lo - Seminars in cancer biology, 2022 - Elsevier
Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
[PDF][PDF] The JAK-STAT pathway at twenty
GR Stark, JE Darnell - Immunity, 2012 - cell.com
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …
STAT3 and its targeting inhibitors in osteosarcoma
Y Liu, S Liao, S Bennett, H Tang, D Song… - Cell …, 2021 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is one of seven STAT family
members involved with the regulation of cellular growth, differentiation and survival. STAT …
members involved with the regulation of cellular growth, differentiation and survival. STAT …
Hepatic acute phase proteins–regulation by IL-6-and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling
JG Bode, U Albrecht, D Häussinger, PC Heinrich… - European journal of cell …, 2012 - Elsevier
The function of the liver as an important constituent of the immune system involved in innate
as well as adaptive immunity is warranted by different highly specialized cell populations. As …
as well as adaptive immunity is warranted by different highly specialized cell populations. As …
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway
C Schindler, JE Darnell Jr - Annual review of biochemistry, 1995 - annualreviews.org
Cytokines and growth factors regulate multiple aspects of cell growth through their
interactions with specific receptors. These receptors initiate signals di rected at both the …
interactions with specific receptors. These receptors initiate signals di rected at both the …
[HTML][HTML] The potential and controversy of targeting STAT family members in cancer
Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …
consists of transcription factors that play a complex and essential role in the regulation of …
Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line: pathways that are shared with and distinct from IL …
D Lejeune, L Dumoutier, S Constantinescu… - Journal of Biological …, 2002 - ASBMB
IL (interleukin)-22 is an IL-10-related cytokine; its main biological activity known thus far is
the induction of acute phase reactants in liver and pancreas. IL-22 signals through a …
the induction of acute phase reactants in liver and pancreas. IL-22 signals through a …
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
N Stahl, TJ Farruggella, TG Boulton, Z Zhong… - Science, 1995 - science.org
Many members of the cytokine receptor superfamily initiate intracellular signaling by
activating members of the Jak family of tyrosine kinases. Activation of the same Jaks by …
activating members of the Jak family of tyrosine kinases. Activation of the same Jaks by …
[PDF][PDF] Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
S Liu, M Umezu-Goto, M Murph, Y Lu, W Liu, F Zhang… - Cancer cell, 2009 - cell.com
Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to
mediate a plethora of physiological and pathological activities associated with …
mediate a plethora of physiological and pathological activities associated with …