Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory
formation. Thus, in the last several years, one main interest of molecular neuroscience has …

Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …

The influence that neurons exert on astrocytic function is poorly understood. To investigate
this, we first developed a system combining cortical neurons and astrocytes from closely …

The ability to adapt to altered availability of free water is a fundamental property of living
cells. The principles underlying osmoadaptation are well conserved. The yeast …

Studies of human addicts and behavioural studies in rodent models of addiction indicate that
key behavioural abnormalities associated with addiction are extremely long lived. So …

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic
processes. Its properties as an energy sensor allow it to couple the energy status of the cell …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

Cyclic adenosine 3′, 5′-monophosphate (cAMP) was originally shown to induce gene
transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent …

The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …