Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

Cell cycle progression and division is regulated by checkpoint controls and sequential
activation of cyclin-dependent kinases (CDKs). Understanding of how these events occur in …

Cancer and stem cells appear to share a common metabolic profile that is characterized by
high utilization of glucose through aerobic glycolysis. In the presence of sufficient nutrients …

Symmetric cell division requires the even partitioning of genetic information and cytoplasmic
contents between daughter cells. Whereas the mechanisms coordinating the segregation of …

Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal
adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …