Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

One of the central questions in neuroscience is how particular tasks, or computations, are
implemented by neural networks to generate behavior. The prevailing view has been that …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons,
little is known about their integrative properties. We have used multisite two-photon …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Voltage-gated ion channels have to be at the right place in the right number to endow
individual neurons with their specific character. Their biophysical properties together with …

Abstract Small-conductance Ca2+-activated K+ channels (SK channels) influence the
induction of synaptic plasticity at hippocampal CA3–CA1 synapses. We find that in mice, SK …