Recently determined structures of the Escherichia coli catabolite activator protein (CAP) in
complex with DNA, and in complex with the RNA polymerase α subunit C-terminal domain …

Helices are essential building blocks of living organisms, be they molecular fragments of
proteins (α-helices), macromolecules (DNA and collagen), or multimolecular assemblies …

Exploring recent developments in the field, Coarse-Graining of Condensed Phase and
Biomolecular Systems examines systematic ways of constructing coarse-grained …

Over the past two decades, significant experimental advances have increased our ability to
control and manipulate individual DNA molecules. This capability has permitted …

We present a systematic study of B-DNA flexibility in aqueous solution using long-scale
molecular dynamics simulations with the two more recent versions of nucleic acids force …

Both clinical and analytical metrics produced by microarray-based assay technology have
recognized problems in reproducibility, reliability and analytical sensitivity. These issues are …

About three quarter of all eukaryotic DNA is wrapped around protein cylinders, forming
nucleosomes. Even though the histone proteins that make up the core of nucleosomes are …

Repression of transcription of the Escherichia coli Lac operon by the Lac repressor (LacR) is
accompanied by the simultaneous binding of LacR to two operators and the formation of a …

Recent work indicates that twist-bend coupling plays an important role in DNA
micromechanics. Here we investigate its effect on bent DNA. We provide an analytical …

The traditional mesoscopic paradigm represents DNA as a series of base-pair steps whose
energy response to equilibrium perturbations is elastic, with harmonic oscillations (defining …