Machine Learning and Deep Learning Strategies for Chinese Hamster Ovary Cell Bioprocess Optimization

TMD Baako, SK Kulkarni, JL McClendon, SW Harcum… - Fermentation, 2024 - mdpi.com
The use of machine learning and deep learning has become prominent within various fields
of bioprocessing for countless modeling and prediction tasks. Previous reviews have …

Cell culture product quality attribute prediction using convolutional neural networks and Raman spectroscopy

H Khodabandehlou, M Rashedi, T Wang… - Biotechnology and …, 2024 - Wiley Online Library
Advanced process control in the biopharmaceutical industry often lacks real‐time
measurements due to resource constraints. Raman spectroscopy and Partial Least Squares …

Integration of just‐in‐time learning with variational autoencoder for cell culture process monitoring based on Raman spectroscopy

M Rashedi, H Khodabandehlou, T Wang… - Biotechnology and …, 2024 - Wiley Online Library
Protein production in the biopharmaceutical industry necessitates the utilization of multiple
analytical techniques and control methodologies to ensure both safety and consistency. To …

Reinforcement learning‐guided control strategies for CAR T‐cell activation and expansion

S Ferdous, IF Shihab, R Chowdhury… - Biotechnology and …, 2024 - Wiley Online Library
Reinforcement learning (RL), a subset of machine learning (ML), could optimize and control
biomanufacturing processes, such as improved production of therapeutic cells. Here, the …

基于PAT 技术的动物细胞培养在线检测研究进展

周光正, 王学重 - 化工进展, 2024 - hgjz.cip.com.cn
动物细胞培养是一项重要的生物工程技术, 在该过程中需要对一些重要的生物和生化指标进行
监测. 目前广泛采用的是取样离线分析手段, 存在时间滞后性和潜在的染菌风险 …

Revolutionizing Pharma: Unveiling the AI and LLM Trends in the Pharmaceutical Industry

Y Han, J Tao - arXiv preprint arXiv:2401.10273, 2024 - arxiv.org
This document offers a critical overview of the emerging trends and significant
advancements in artificial intelligence (AI) within the pharmaceutical industry. Detailing its …

Progress on on-line monitoring for animal cell culture based on PAT technology

G ZHOU, X WANG - Chemical Industry and Engineering Progress, 2024 - hgjz.cip.com.cn
As an important technique in biotechnology and bioengineering, animal cell culture often
requires frequent analysis and monitoring of some key biomass and biochemical properties …

Neural Network Fuzzy Predictive Control for Penicillin Production from Biomass

B Cosenza, M Miccio, G Pannocchia… - Chemical Engineering …, 2024 - cetjournal.it
Abstract b Dipartimento di Ingegneria Industriale (DIIn), Università degli Studi di Salerno, via
Giovanni Paolo II 132, 84084 Fisciano (SA), Italy, michele. miccio@ unisa. itThis work …

Sistema de control basado en machine learning para cultivo celular en modo fed-batch considerando datos de un modelo cinético para el metabolismo central de …

TAM Pérez Ushijima - 2024 - repositorio.uchile.cl
En los últimos años la industria a nivel global ha presentado innovación en términos de la
implementación de tecnologías basadas en la Industria 4.0., incluyendo la inteligencia …

JAYA Optimization Inherited Self-Organizing Fuzzy Sliding-Mode Controller for Wastewater Treatment

V Kumara, E Ganesan - 2024 - researchsquare.com
Background: Due to the rising demand for water, wastewater treatment processes (WWTPs)
gain huge attention. However, operating WWTPs is complex due to the physical, chemical …