The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
Delivery of nucleic acids, such as mRNA, to immune cells has become a major focus in the
past decade with ionizable lipid nanoparticles (LNPs) emerging as a clinically-validated …
past decade with ionizable lipid nanoparticles (LNPs) emerging as a clinically-validated …
Recent advancement in mRNA vaccine development and applications
N Al Fayez, MS Nassar, AA Alshehri, MK Alnefaie… - Pharmaceutics, 2023 - mdpi.com
Messenger RNA (mRNA) vaccine development for preventive and therapeutic applications
has evolved rapidly over the last decade. The mRVNA vaccine has proven therapeutic …
has evolved rapidly over the last decade. The mRVNA vaccine has proven therapeutic …
[HTML][HTML] Engineered cell entry links receptor biology with single-cell genomics
Cells communicate with each other via receptor-ligand interactions. Here, we describe
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …
Recent advances in lipid nanoparticles for delivery of mRNA
L Yang, L Gong, P Wang, X Zhao, F Zhao, Z Zhang… - Pharmaceutics, 2022 - mdpi.com
Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic
information and direct protein synthesis, is transcribed from a strand of DNA as a template …
information and direct protein synthesis, is transcribed from a strand of DNA as a template …
Fluorinated Lipid Nanoparticles for Enhancing mRNA Delivery Efficiency
H Zhang, C Meng, X Yi, J Han, J Wang, F Liu, Q Ling… - ACS …, 2024 - ACS Publications
Lipid nanoparticles (LNPs), a nonviral nucleic acid delivery system, have shown vast
potential for vaccine development and disease treatment. LNPs assist mRNA to cross …
potential for vaccine development and disease treatment. LNPs assist mRNA to cross …
mRNA nanodelivery systems: targeting strategies and administration routes
M Yuan, Z Han, Y Liang, Y Sun, B He… - Biomaterials …, 2023 - spj.science.org
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …
In vivo gene immunotherapy for cancer
Cancer is becoming increasingly understood not only as a disease of pathological cells but
also as one of immune hypofunction. The heterogenous and patient-specific nature of …
also as one of immune hypofunction. The heterogenous and patient-specific nature of …