Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …

Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is …

Biomolecular condensates are thought to create subcellular microenvironments that
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …

Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …

Liquid–liquid phase separation (LLPS) plays a critical role in regulating gene transcription
via the formation of transcriptional condensates. However, LLPS has not been reported to be …

Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …

Chromatin reader domains are protein folds that bind to post-translational modifications of
histones and other chromatin-associated proteins. Compared to other families of reader …

Highlights•Microenvironments are local high concentrations of multiple nuclear factors.•
Microenvironments form due to protein–protein and protein–chromatin interactions.•Local …

Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …