The process of engulfing a foreign particle–phagocytosis–is of fundamental importance for a
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome
acidification and maturation processes after engulfment by macrophages. Here, we show …

Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of
phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their …

Nascent phagosomes must undergo a series of fusion and fission reactions to acquire the
microbicidal properties required for the innate immune response. Here we demonstrate that …

In the last decade a tremendous progress has been achieved in understanding the control of
apoptosis by survival and death factors as well as the molecular mechanisms of preparation …

Adult humans have about 25 trillion red blood cells (RBCs), and each second we recycle
about 5 million RBCs by erythrophagocytosis (EP) in macrophages of the reticuloendothelial …

Aspergillus fumigatus is the most prevalent airborne fungal pathogen responsible for fatal
invasive aspergillosis in immunocompromised patients. Upon arrival in the lung alveolus …

Rapid discharge of secretory organelles called rhoptries is tightly coupled with host cell
entry by the protozoan parasite Toxoplasma gondii. Rhoptry contents were deposited in …

Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 μm in
diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to …