Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder
AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
S Sabate‐Soler, SL Nickels, C Saraiva, E Berger… - Glia, 2022 - Wiley Online Library
The human brain is a complex, three‐dimensional structure. To better recapitulate brain
complexity, recent efforts have focused on the development of human‐specific midbrain …
complexity, recent efforts have focused on the development of human‐specific midbrain …
Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression
Background Depression is a complex neuropsychiatric syndrome that is often very severe
and life threatening. In spite of the remarkable progress in understanding the neural biology …
and life threatening. In spite of the remarkable progress in understanding the neural biology …
1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo
Quantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive
imaging contributes to our understanding of the initiation and progression of diseases …
imaging contributes to our understanding of the initiation and progression of diseases …
Astrocytes: new targets for the treatment of neurodegenerative diseases
C Finsterwald, PJ Magistretti… - Current pharmaceutical …, 2015 - ingentaconnect.com
The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic
understanding is still lacking. However, neurodegenerative diseases such as Alzheimer …
understanding is still lacking. However, neurodegenerative diseases such as Alzheimer …
Glutamine-glutamate cycle flux is similar in cultured astrocytes and brain and both glutamate production and oxidation are mainly catalyzed by aspartate …
L Hertz, DL Rothman - Biology, 2017 - mdpi.com
The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-
aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released …
aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released …
Mini-review: brain energy metabolism and its role in animal models of depression, bipolar disorder, schizophrenia and autism
D Kolar, L Kleteckova, H Brozka, K Vales - Neuroscience letters, 2021 - Elsevier
Mitochondria are cellular organelles essential for energy metabolism and antioxidant
defense. Mitochondrial impairment is implicated in many psychiatric disorders, including …
defense. Mitochondrial impairment is implicated in many psychiatric disorders, including …
How Energy Metabolism Supports Cerebral Function: Insights from 13C Magnetic Resonance Studies In vivo
S Sonnay, R Gruetter, JMN Duarte - Frontiers in neuroscience, 2017 - frontiersin.org
Cerebral function is associated with exceptionally high metabolic activity, and requires
continuous supply of oxygen and nutrients from the blood stream. Since the mid-twentieth …
continuous supply of oxygen and nutrients from the blood stream. Since the mid-twentieth …
Synaptic mitochondria: a brain mitochondria cluster with a specific proteome
K Völgyi, P Gulyássy, K Háden, V Kis, KA Kékesi… - Journal of …, 2015 - Elsevier
The synapse is a particularly important compartment of neurons. To reveal its molecular
characteristics we isolated whole brain synaptic (sMito) and non-synaptic mitochondria …
characteristics we isolated whole brain synaptic (sMito) and non-synaptic mitochondria …