Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

The roundworm Caenorhabditis elegans has risen to the status of a top model organism for
biological research in the last fifty years. Among laboratory animals, this tiny nematode is …

Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …

Across diverse taxa, selfing species have evolved independently from outcrossing species
thousands of times. The transition from outcrossing to selfing decreases the effective …

Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple
roles in immunity, including direct elimination of intracellular microorganisms via …

Microsporidia are a large group of fungal‐related obligate intracellular parasites. They are
responsible for infections in humans as well as in agriculturally and environmentally …

Microbes associated with an organism can significantly modulate its susceptibility to viral
infections, but our understanding of the influence of individual microbes remains limited. The …

During aging, proteostasis capacity declines and distinct proteins become unstable and can
accumulate as protein aggregates inside and outside of cells. Both in disease and during …