Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …

Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative
pathologies, but the molecular and cellular changes underlying pathological aging of the …

Background Elderly patients often exhibit postoperative cognitive dysfunction (POCD), a
postsurgical decline in memory and executive function. Oxidative stress and …

Alzheimer's disease (AD) is the most common cause of age-related dementia. Neuronal
calcium homeostasis impairment may contribute to AD. Here we demonstrated that voltage …

Simple Summary Age-related cardiovascular disease is the foremost cause of death
globally. Despite medical advances, we have been unable to stop or reverse the underlying …

Cellular senescence and biliary fibrosis are prototypical features of obliterative
cholangiopathies, such as primary sclerosing cholangitis (PSC). Telomere dysfunction can …

Ageing is characterized by the progressive loss of cellular homeostasis, leading to an
overall decline of the organism's fitness. In the brain, ageing is highly associated with …

Background Fatigue is a common symptom in neurodegenerative diseases and is
associated with decreased cognitive performances. A full knowledge of the causes and …

Telomerase preserves genomic integrity by maintaining and protecting the telomeres.
Seminal findings from 1985 revealed the canonical role of telomerase and motivated …