The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

however, this characteristic twisting morphology may not be evident in all ECG leads.
Second, episodes of drug-induced TdP usually start with a short-long-short pattern of RR …

The single most common cause of the withdrawal or restriction of the use of marketed drugs
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …

Objective: To attempt to determine the relative value of preclinical cardiac electrophysiology
data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use …

Kléber, André G., and Yoram Rudy. Basic Mechanisms of Cardiac Impulse Propagation and
Associated Arrhythmias. Physiol Rev 84: 431–488, 2004; 10.1152/physrev. 00025.2003 …

The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …

The prolonged QT interval is both widely seen and associated with the potentially deadly
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …

Background—DNA variants appearing to predispose to drug-associated “acquired” long-QT
syndrome (aLQTS) have been reported in congenital long-QT disease genes. However, the …

Background—Drug-induced QT prolongation and torsades de pointes remain significant
and often unpredictable clinical problems. Current in vitro preclinical assays are limited by …

For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce
QT interval prolongation and Torsades de Pointes (TdP) arrhythmia has been conducted …