Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as
key components of licensed vaccines, with over 100 million doses administered to diverse …

The deployment of effective vaccines against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID …

Vaccines aim to elicit a robust, yet targeted, immune response. Failure of a vaccine to elicit
such a response arises in part from inappropriate temporal control over antigen and …

The innate immune mechanisms by which adjuvants enhance the potency and protection of
vaccine-induced adaptive immunity are largely unknown. We introduce a model to delineate …

Many autoimmune disorders such as psoriasis lead to the alteration of skin components
which generally manifests as unwanted topical symptoms. One of the most widely approved …

Preserving good health in old age is of utmost importance to alleviate societal, economic
and health care-related challenges caused by an aging society. The prevalence and …

Highlights•Most current vaccines are less immunogenic and efficient in the older
population.•New adjuvants have improved vaccination success for several …

Aluminum salts and squalene based oil-in-water emulsions (SE) are widely used adjuvants
in licensed vaccines, yet their mechanisms are not fully known. Here we report that induction …

The success of most vaccines relies on the generation of antibodies to provide protection
against subsequent infection; this in turn depends on a robust germinal centre (GC) …