Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Solid-state NMR has been increasingly recognized as a high-resolution and versatile
spectroscopic tool to characterize drug substances and products. However, the analysis of …

High-resolution solid-state analysis of multicomponent molecular systems, eg,
pharmaceutical formulations, is a great challenge. Solid-state nuclear magnetic resonance …

Crystalline and amorphous materials usually possess distinct physicochemical properties
due to major variations in long-range and local molecular packings. Enhanced fundamental …

The presence of fluorine in an active pharmaceutical ingredient (API) can impart important
pharmacological attributes with regards to metabolism, stability, and selectivity. As such …

This article presents some of the solid-state NMR (SSNMR) techniques used in the
pharmaceutical and biomedical research. Solid-state magic angle spinning (MAS) NMR …

The lower detection limit for 2 distinct crystalline phases by 1 H magic-angle spinning (MAS)
solid-state nuclear magnetic resonance (NMR) is investigated for a minority amount of …

Quantitative nuclear magnetic resonance (q-NMR) spectroscopy is a robust and reliable
analytical method that possesses many advantages over conventional chromatographic …

Probing form conversions of active pharmaceutical ingredients in solid dosages is critical for
understanding the physicochemical stability of drug substances in formulations. The …

The so-called pharmaceutical solid chain, which encompasses drug substance
micronisation to the final tablet production, at pilot plant scale is presented as a case study …