PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing
for hereditary cancer syndromes, providing relatives the opportunity for early detection and …

Nearly 3% of the population carries genetic variants that lead to conditions that include
hereditary breast and ovarian cancer and Lynch syndrome. These pathogenic variants …

The spectrum of germline predisposition in pediatric cancer continues to be realized. Here
we report 751 patients with solid tumors who underwent prospective matched tumor–normal …

Importance Germline genetic testing is recommended by practice guidelines for patients
diagnosed with cancer to enable genetically targeted treatment and identify relatives who …

Background Germline risk assessment is increasing as part of cancer care; however,
disparities in subsequent genetic counseling are unknown. Methods Pan‐cancer patients …

Importance Personalized surveillance, prophylaxis, and cancer treatment options for
individuals with hereditary cancer predisposition are informed by results of germline genetic …

Purpose To address demands for timely germline information to guide treatments, we
evaluated experiences of patients with ovarian, pancreatic, and prostate cancer with a …

PURPOSE A powerful consequence of detecting cancer-associated pathogenic variants is
the ability to test at-risk relatives (ARRs), termed cascade testing. However, historical studies …

Hereditary cancer syndromes (HCS) account for 5~ 10% of all cancer diagnosis. Lynch
syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA …

Background We sought to determine the prevalence of germline pathogenic variants (gPVs)
in unselected patients with endometrial cancer (EC), define biallelic gPVs within tumors, and …