Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Regulation of gene expression by cis-acting long non-coding RNAs
N Gil, I Ulitsky - Nature Reviews Genetics, 2020 - nature.com
Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …
Transcription shapes 3D chromatin organization by interacting with loop extrusion
EJ Banigan, W Tang… - Proceedings of the …, 2023 - National Acad Sciences
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles
CM Uyehara, E Apostolou - Cell reports, 2023 - cell.com
The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …
regulatory sequences, called enhancers, which regulate target genes over variable genomic …
Looping the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
[HTML][HTML] SMC complexes can traverse physical roadblocks bigger than their ring size
Ring-shaped structural maintenance of chromosomes (SMC) complexes like condensin and
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
Mechanisms of chromosome folding and nuclear organization: their interplay and open questions
Microscopy and genomic approaches provide detailed descriptions of the three-dimensional
folding of chromosomes and nuclear organization. The fundamental question is how activity …
folding of chromosomes and nuclear organization. The fundamental question is how activity …
Two major mechanisms of chromosome organization
The spatial organization of chromosomes has long been connected to their polymeric nature
and is believed to be important for their biological functions, including the control of …
and is believed to be important for their biological functions, including the control of …
Transcription-induced domains form the elementary constraining building blocks of bacterial chromosomes
A Bignaud, C Cockram, C Borde, J Groseille… - Nature Structural & …, 2024 - nature.com
Transcription generates local topological and mechanical constraints on the DNA fiber,
leading to the generation of supercoiled chromosome domains in bacteria. However, the …
leading to the generation of supercoiled chromosome domains in bacteria. However, the …
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis
Mammalian chromosomes are three-dimensional entities shaped by converging and
opposing forces. Mitotic cell division induces marked chromosome condensation, but …
opposing forces. Mitotic cell division induces marked chromosome condensation, but …