Carboxypeptidase N (CPN) is a plasma zinc metalloprotease, which consists of two
enzymatically active small subunits (CPN1) and two large subunits (CPN2) that protect the …

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …

The chemokine stromal-derived factor-1α (SDF-1α) is an essential regulator of
hematopoiesis, lymphocyte homing, pre-B-cell growth, and angiogenesis. As SDF-1α is …

Human carboxypeptidase N (CPN) was discovered in the early 1960s as a plasma enzyme
that inactivates bradykinin and was identified 8 years later as the major “anaphylatoxin …

Carboxypeptidase N (CPN) is a plasma zinc metalloprotease, which consists of two
enzymatically active small subunits (CPN1) and two large subunits (CPN2) that protect the …

Oligopeptides are important markers of protein metabolism, as they are cleaved from larger
polypeptides and proteins. Genetic association studies may help elucidate their origin and …

Carboxypeptidases (CPs) are proteases that hydrolyze C-terminal peptide bonds. They are
involved in regulating the complement system of the immune system. Here, we report the …

Human carboxypeptidase D (CPD) is a 180-kDa type I membrane protein with three tandem
active site domains. CPD is a B-type (or kininase I-type) carboxypeptidase that cleaves C …

The human carboxypeptidase M (CPM) gene was found to encompass∼ 112.6 kb of
genomic sequence, containing 11 exons of which eight (exons 2–9) are common to all …

Complement regulatory proteins prevent excessive complement system activation and
deposition, which can lead to host tissue damage, including fetal loss during pregnancy. To …