Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …

Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant
on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in …

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the
gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear …

The gastrointestinal (GI) microbiome of cats and dogs is increasingly recognized as a
metabolically active organ inextricably linked to pet health. Food serves as a substrate for …

Background The composition of the bile acid (BA) pool is closely associated with obesity
and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition …

The gut microbiome is an important immune and metabolic organ. Intestinal bacteria
produce various metabolites that influence the health of the intestine and other organ …

Aims Inflammatory bowel disease (IBD) patients are accompanied by impaired intestinal
barrier integrity and gut microbiota dysbiosis. Strategies targeting the gut microbiota are …

Background Neurodegenerative diseases are debilitating conditions that diminish the
quality of life and pose significant financial and social burdens. Therefore, strategies to …