The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

New therapeutic approaches to and mechanisms of ginsenoside Rg1 against neurological diseases

Y Sun, Y Yang, S Liu, S Yang, C Chen, M Lin, Q Zeng… - Cells, 2022 - mdpi.com
Neurological diseases, including Parkinson's disease (PD), Alzheimer's disease (AD),
Huntington's disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury …

Immunomodulatory, anti-inflammatory, and anti-cancer properties of ginseng: a pharmacological update

JA Valdés-González, M Sánchez, I Moratilla-Rivera… - Molecules, 2023 - mdpi.com
Ginseng, a medicinal plant of the genus Panax, boasts a rich historical record of usage that
dates back to the Paleolithic period. This botanical is extensively acknowledged and …

Therapeutic application of natural products: NAD+ metabolism as potential target

C Guo, Q Huang, Y Wang, Y Yao, J Li, J Chen, M Wu… - Phytomedicine, 2023 - Elsevier
Background Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …

Ginsenosides in cancer: Targeting cell cycle arrest and apoptosis

MA Shah, SM Abuzar, K Ilyas, I Qadees, M Bilal… - Chemico-biological …, 2023 - Elsevier
Despite the existence of extensive clinical research and novel therapeutic treatments,
cancer remains undefeated and the significant cause of death worldwide. Cancer is a …

Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms

J Chen, Q Huang, J Li, Y Yao, W Sun, Z Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Panax ginseng CA Meyer (P. ginseng) is effective in the
prevention and treatment of myocardial ischemia-reperfusion (I/R) injury. The mechanism by …

Activation of ULK1 to trigger FUNDC1-mediated mitophagy in heart failure: effect of Ginsenoside Rg3 intervention

X Wang, G Ling, Y Wei, W Li, Y Zhang, N Tan, W Li… - Phytomedicine, 2023 - Elsevier
Background Although the development of therapies for heart failure (HF) continues apace,
clinical outcomes are often far from ideal. Unc51-like-kinase 1 (ULK1)-mediated mitophagy …

[HTML][HTML] Ginsenoside Rg3 inhibits angiogenesis in gastric precancerous lesions through downregulation of Glut1 and Glut4

Z Zeng, Q Nian, N Chen, M Zhao, Q Zheng… - Biomedicine & …, 2022 - Elsevier
Abstract Ginsenoside Rg3 (GRg3) is a ginsenoside extracted from Panax ginseng. GRg3
displays multiple pharmacological properties, such as antitumor, anti-inflammatory …

Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease

L Wang, Y Zhang, Z Song, Q Liu, D Fan, X Song - Food & Function, 2023 - pubs.rsc.org
Lung cancer is the malignancy with the highest morbidity and mortality. Additionally,
pulmonary inflammatory diseases, such as pneumonia, acute lung injury, chronic obstructive …

Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics

AH El‐Far, SK Al Jaouni, X Li, J Fu - Phytotherapy Research, 2022 - Wiley Online Library
Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …