The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …

Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …

Abstract Changes in memory performance are one of the hallmark symptoms of mild
cognitive impairment and are affected by healthy aging as well. Pattern separation, which …

Functional plasticity of the brain decreases during ageing causing marked deficits in
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …

The ability to find one's way in our complex environments represents one of the most
fundamental cognitive functions. Although involving basic perceptual and memory related …

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

The ability to encode and retrieve our daily personal experiences, called episodic memory,
is supported by the circuitry of the medial temporal lobe (MTL), including the hippocampus …