Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

It is well‏‏ established that macrophages are key regulators of wound healing, displaying
impressive plasticity and an evolving phenotype, from an aggressive pro-inflammatory or" …

Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …

Tissue repair after injury is a complex, metabolically demanding process. Depending on the
tissue's regenerative capacity and the quality of the inflammatory response, the outcome is …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …

The healing of cutaneous wounds is dependent on the progression through distinct, yet
overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-
13, which can either be host protective or have pathogenic activity. Type 2 immunity …