Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Angiogenesis plays an important role in the remodeling process of the ischemic brain and
the recovery of neurological function after ischemic stroke. Ginsenoside Rg1 has been …

Injuries to the CNS lead to severe and often irreversible deficits in sensorimotor and
autonomous function. In spinal cord injury (SCI), mechanical damage results in the death of …

Neurodegenerative diseases are among the leading causes of disability and death
worldwide. The disease-related socioeconomic burden is expected to increase with the …

After traumatic brain injury (TBI) elderly patients suffer from higher mortality rate and worse
functional outcome compared to young patients. However, experimental TBI research is …

Given strong regional specialization of the brain, cerebral angiogenesis may be regionally
modified during normal aging. To test this hypothesis, expression of a broad cadre of …

Emerging understanding of brain plasticity has opened new avenues for the treatment of
stroke. The promising preclinical evidence with neuroprotective drugs has not been …

We previously showed that newly formed vessels in ischemic rat brain have high blood-
brain barrier (BBB) permeability at 3 weeks after stroke due to a lack of major endothelial …

The blood–brain barrier (BBB) has many important functions in maintaining the brain's
immune-privileged status. Endothelial cells, astrocytes, and pericytes have important roles in …