Stroke has long been regarded as focal disease with circumscribed damage leading to
neurological deficits. However, advances in methods for assessing the human brain and in …

The brain has an intrinsic capacity to compensate for structural damage through
reorganizing of surviving networks. These processes are fundamental for recovery of …

Damage to the corticospinal tract is a leading cause of motor disability, for example in stroke
or spinal cord injury. Some function usually recovers, but whether plasticity of undamaged …

An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

The primate reticulospinal tract is usually considered to control proximal and axial muscles,
and to be involved mainly in gross movements such as locomotion, reaching and posture …

Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of
either arm. What is the nature and role of activity across the two hemispheres? We recorded …

Identification of optimal treatment strategies to improve recovery is limited by the incomplete
understanding of the neurobiological principles of recovery. Motor cortex (M1) …

Planning object-directed hand actions requires successful integration of the movement goal
with the acting limb. Exactly where and how this sensorimotor integration occurs in the brain …

Movements of the upper limb are controlled mostly through the contralateral hemisphere.
Although overall activity changes in the ipsilateral motor cortex have been reported, their …

Early evolution of the motor cortex included development of connections to brainstem
reticulospinal neurons; these projections persist in primates. In this study, we examined the …