p53 as a potential target for treatment of cancer: A perspective on recent advancements in small molecules with structural insights and SAR studies
Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …
researched tumour suppressor protein. It is commonly considered the “guardian of the …
A novel alpha‐amylase inhibitor‐based spirooxindole‐pyrrolidine‐clubbed thiochromene‐pyrzaole pharmacophores: Unveiling the [3+ 2] cycloaddition reaction by …
MS Islam, AM Al‐Majid, M Haukka… - Chemical Biology & …, 2023 - Wiley Online Library
A novel spirooxindole‐pyrrolidine clubbed thiochromene and pyrazole motifs were
synthesized by [3+ 2] cycloaddition (32CA) reactions in one step process starting from the …
synthesized by [3+ 2] cycloaddition (32CA) reactions in one step process starting from the …
Novel spirooxindole-triazole derivatives: unveiling [3+ 2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity …
I Shawish, S Al Ayoubi, A El-Faham, A Aldalbahi… - Frontiers in …, 2024 - frontiersin.org
A novel analogue of hybrid spirooxindoles was synthesized employing a systematic
multistep synthetic approach. The synthetic protocol was designed to obtain a series of …
multistep synthetic approach. The synthetic protocol was designed to obtain a series of …
Advancements in targeting tumor suppressor genes (p53 and BRCA 1/2) in breast cancer therapy
Globally, among numerous cancer subtypes, breast cancer (BC) is one of the most prevalent
forms of cancer affecting the female population. A female's family history significantly …
forms of cancer affecting the female population. A female's family history significantly …
New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis …
A Barakat, S Alshahrani, AM Al-Majid… - Journal of Enzyme …, 2023 - Taylor & Francis
Despite the crucial role of CDK2 in tumorigenesis, few inhibitors reached clinical trials for
managing lung cancer, the leading cause of cancer death. Herein, we report combinatorial …
managing lung cancer, the leading cause of cancer death. Herein, we report combinatorial …
Utilizing MEDT analysis of [3+ 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework
AA Alayyaf, M Ali, MA Alwehaibi, MK Al-Muhanna… - BMC chemistry, 2024 - Springer
Hybridization of spirooxindole with different pharmacophores such as triazole and
heterocycle such as thiophene and furan moiety was achieved by the [3+ 2] cycloaddition …
heterocycle such as thiophene and furan moiety was achieved by the [3+ 2] cycloaddition …
Rational design, synthesis, separation, and characterization of new spiroxindoles combined with benzimidazole scaffold as an MDM2 inhibitor
S Alshahrani, AM Al-Majid, M Ali, AS Alamary… - Separations, 2023 - mdpi.com
Rational design for a new spiroxindoles, combined with a benzimidazole scaffold to identify
a new murine double minute two (MDM2) inhibitor was synthesized and characterized. The …
a new murine double minute two (MDM2) inhibitor was synthesized and characterized. The …
Exploring Regio-and Stereoselectivity in [3+ 2] Cycloaddition: Molecular Electron Density Theory Approach for Novel Spirooxindole-Based Benzimidazole with …
S Alshahrani, AM Al-Majid, AS Alamary… - Crystals, 2023 - mdpi.com
A new ethylene derivative was synthesized as a precursor for the [3+ 2] cycloaddition
(32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a …
(32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a …
Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules
A Barakat, S Alshahrani, AM Al-Majid… - Frontiers in …, 2024 - frontiersin.org
This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole
compounds as inhibitors of the signal transducer and activator of p53, a protein involved in …
compounds as inhibitors of the signal transducer and activator of p53, a protein involved in …
Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+ 2] Cycloaddition Reaction: An MEDT Study of …
S Alshahrani, AM Al-Majid, AS Alamary, M Ali… - Molecules, 2023 - mdpi.com
A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were
synthesized via a [3+ 2] cycloaddition reaction protocol in one step. The single X-ray crystal …
synthesized via a [3+ 2] cycloaddition reaction protocol in one step. The single X-ray crystal …