Invasive bilirubin measurements remain the gold standard for the diagnosis and treatment of
infants with severe neonatal hyperbilirubinemia. The present paper describes different …

Objective Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the
tissue and is indicative of potential toxicity to the brain. Since its very first description more …

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …

Nonintegrative AAV-mediated gene therapy in the liver is effective in adult patients but faces
limitations in pediatric settings because of episomal DNA loss during hepatocyte …

Neonatal hyperbilirubinemia or jaundice is associated with kernicterus, resulting in
permanent neurological damage or even death. Conventional phototherapy does not …

Background Severe hyperbilirubinemia is toxic during central nervous system development.
Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced …

Background Hyperbilirubinemia occurs when the liver fails to process bilirubin properly. A
disproportionate increase in direct bilirubin indicates a decreased ability of the hepatocytes …

Psoriatic inflammation has been shown to be associated with cardiovascular dysfunction
and systemic inflammation. Recently, psoriasis has also been linked to hepatic disorders …

Background and Aim: Hepatic encephalopathy (HE) is a neurological disease caused by
severe liver disease. Early identification of the risk factor is beneficial to the prevention and …

Increased concentrations of unconjugated bilirubin (UCB), namely its free fraction (Bf), in
neonatal life may cause transient or definitive injury to neurons and glial cells. We …