[HTML][HTML] Thick filament protein network, functions, and disease association

L Wang, J Geist, A Grogan, LYR Hu… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …

Barley Ror1 encodes a class XI myosin required for mlo‐based broad‐spectrum resistance to the fungal powdery mildew pathogen

J Acevedo‐Garcia, K Walden, F Leissing… - The Plant …, 2022 - Wiley Online Library
Loss‐of‐function alleles of plant MLO genes confer broad‐spectrum resistance to powdery
mildews in many eudicot and monocot species. Although barley (Hordeum vulgare) mlo …

Investigation of the recovery stroke and ATP hydrolysis and changes caused due to the cardiomyopathic point mutations in human cardiac β myosin

A Chakraborti, AP Baldo, JC Tardiff… - The Journal of Physical …, 2021 - ACS Publications
Human cardiac β myosin undergoes the cross-bridge cycle as part of the force-generating
mechanism of cardiac muscle. The recovery stroke is considered one of the key steps of the …

Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin

W Tang, J Ge, WC Unrath, R Desetty, CM Yengo - Biophysical journal, 2021 - cell.com
Cardiac muscle contraction is driven by the molecular motor myosin, which uses the energy
from ATP hydrolysis to generate a power stroke when interacting with actin filaments …

Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil

W Tang, WC Unrath, R Desetty, CM Yengo - Journal of Biological Chemistry, 2019 - ASBMB
We investigated a dilated cardiomyopathy (DCM) mutation (F764L) in human β-cardiac
myosin by determining its motor properties in the presence and absence of the heart failure …

Converter domain mutations in myosin alter structural kinetics and motor function

LK Gunther, JA Rohde, W Tang, SD Walton… - Journal of Biological …, 2019 - ASBMB
Myosins are molecular motors that use a conserved ATPase cycle to generate force. We
investigated two mutations in the converter domain of myosin V (R712G and F750L) to …

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

K Chinthalapudi, SM Heissler, M Preller, JR Sellers… - Elife, 2017 - elifesciences.org
Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation
by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre …

Mechanochemical function of myosin II: investigation into the recovery stroke and ATP hydrolysis

AP Baldo, JC Tardiff, SD Schwartz - The Journal of Physical …, 2020 - ACS Publications
Myosin regulates muscle function through a complex cycle of conformational
rearrangements coupled with the hydrolysis of adenosine triphosphate (ATP). The recovery …

Effect of bovine myosin heavy chain 3 on proliferation and differentiation of myoblast

J Tang, B Yang, G Song, X Zhang, Z Wang… - Animal …, 2023 - Taylor & Francis
The myosin heavy chain 3 (MYH3) gene is an essential gene that affects muscle
development. This study aimed to discuss the expression characteristics of the MYH3 gene …

Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin

J Hao, C Liu, N Zhang, J Li, T Ni, M Qu, X Li - Insect Science, 2024 - Wiley Online Library
Locust (Locusta migratoria) has a single striated muscle myosin heavy chain (Mhc) gene,
which contains 5 clusters of alternative exclusive exons and 1 differently included …