Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …

Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

The human ATP-binding cassette transporter multidrug resistance protein 1 (MRP1),
encoded by ABCC1, was initially identified because of its ability to confer multidrug …

While chemotherapy remains the most effective treatment for disseminated tumors, acquired
or intrinsic drug resistance accounts for approximately 90% of treatment failure. Multidrug …

The development of multidrug resistance (MDR) in patients suffering cancer remains a
significant clinical challenge, with drug efflux by ABC (ATP-binding cassette) transporters …