Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …

Accumulating evidence suggests that the gut microbiome influences the brain functions and
psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

The obesity epidemic has been widely publicized in the media worldwide. Investigators at all
levels have been looking for factors that have contributed to the development of this …

The popular media and personal anecdotes are rich with examples of stress-induced eating
of calorically dense “comfort foods.” Such behavioral reactions likely contribute to the …

The increased recognition that the worldwide increase in incidence of obesity is due to a
positive energy balance has lead to a focus on lifestyle choices that may contribute to …