In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

How antigen valency affects B cells in vivo during immune responses is not well understood.
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …

Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …

Although adoptive T-cell therapy holds promise for the treatment of many cancers, its clinical
utility has been limited by problems in delivering targeted lymphocytes to tumor sites, and …

Multiphoton microscopy (MPM) has found a niche in the world of biological imaging as the
best noninvasive means of fluorescence microscopy in tissue explants and living animals …

Primary T-cell responses in lymph nodes (LNs) require contact-dependent information
exchange between T cells and dendritic cells (DCs). Because lymphocytes continually enter …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Lymph nodes (LNs) are the organs where innate immune responses lead to acquired
immunity, where some of our most devastating pathogens evade immunity, and where …