This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …

The vascular hypothesis used to explain the pathophysiology of Alzheimer's disease (AD)
suggests that a dysfunction of the cerebral microvasculature could be the beginning of …

Abstract 3′, 5′-Cyclic adenosine monophosphate (cAMP) exerts an endothelium-
dependent vasorelaxant action by stimulating endothelial NO synthase (eNOS) activity, and …

The antihypertensive activity of yeast hydrolysate (YH) was confirmed in our previous study.
However, the critical peptides in YH and the underlying mechanisms have not been fully …

Cardiovascular disease (CVD) is one of the leading causes of death and disability, and has
always been a hotspot in clinical and scientific research. The illness brings a heavy …

Objective—To establish the role of Kv7 channels in EPAC (exchange protein directly
activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether …

Aims The uremic toxin indoxyl sulfate (IS) was reported to be the cause of cardiovascular
disease associated with chronic kidney disease. Therefore, we evaluated the direct …

In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary
messenger, and the first signaling cascade discovered was the cAMP-protein kinase A …

Metabolic regulation of cerebrovascular tone directs blood flow to areas of increased
neuronal activity and during disease states partially compensates for insufficient perfusion …