▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

Histone acetylation regulates many cellular processes, and specific acetylation marks, either
singly or in combination, produce distinct outcomes. For example, the acetylation pattern on …

Roger D. Kornberg* and Yahli Lorch Department of Structural Biology Stanford University
School of Medicine Stanford, California 94305 model building and other predictive structural …

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

More than 30 years ago, Vincent Allfrey proposed that histone acetylation was associated
with transcriptional activity in eukaryotic cells (Allfrey et al. 1964; Pogo et al. 1966) …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

Acetylation of internal lysine residues of core histone N‐terminal domains has been found
correlatively associated with transcriptional activation in eukaryotes for more than three …

Eukaryotic genomes are packaged into nucleosomes whose position and chemical
modification state can profoundly influence regulation of gene expression. We profiled …

The enzyme‐catalyzed acetylation of the N‐terminal tail domains of core histones provides a
rich potential source of epigenetic information. This may be used both to mediate transient …

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …